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CS-W001157 4
Total: USD 88.00

4-(Prop-2-yn-1-yl)piperidine hydrochloride

  • CAS No. 2172188-51-9

  • Cat. No. CS-0513843
  • Purity≥97%
  • MDL No.MFCD31616367
  • HazMat Fee +

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    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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*For research and further manufacturing use only, not for direct human use.

4-(Prop-2-yn-1-yl)piperidine hydrochloride|CS-0513843

Structure of 2172188-51-9

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Description

4-(Prop-2-yn-1-yl)piperidine hydrochloride features a terminal alkyne group tethered to a piperidine nitrogen, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation and click chemistry applications. The hydrochloride salt enhances solubility and stability in aqueous and polar organic media, facilitating handling under standard bench conditions.

Application

4-(Prop-2-yn-1-yl)piperidine hydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient access to alkynyl-functionalized heterocycles via copper-catalyzed azide-alkyne cycloaddition (CuAAC). The terminal alkyne group exhibits high reactivity in click chemistry protocols, while the piperidine nitrogen provides a handle for further derivatization. Its crystalline hydrochloride salt ensures excellent bench stability, ease of handling, and straightforward purification—ideal for scalable synthesis and library generation.

General Information

  • CAS No. 2172188-51-9
  • Cat. No. CS-0513843
  • Purity ≥97%
  • MDL No. MFCD31616367
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₄ClN
  • Molecular Weight 159.66
  • Synonym(s) 4-Prop-2-ynylpiperidine; hydrochloride
  • SMILES C#CCC1CCNCC1.Cl

Computational Chemistry Data

  • TPSA   12.03
  • LogP   1.4311
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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