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Structure of 217813-00-8
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4,5-Difluoro-2-(trimethylsilyl)phenyl trifluoromethanesulfonate serves as a highly reactive aryl triflate for cross-coupling reactions. The electron-deficient aryl ring enhances reactivity in palladium-catalyzed transformations, while the trimethylsilyl group provides steric protection and facilitates orthogonal deprotection. This derivative enables efficient C–C bond formation under mild conditions.
4,5-Difluoro-2-(trimethylsilyl)phenyl trifluoromethanesulfonate serves as a highly effective aryl triflate building block for palladium-catalyzed cross-coupling reactions. The ortho-trimethylsilyl group enhances stability and facilitates regioselective functionalization, while the difluoro substitution pattern improves electrophilicity and compatibility with diverse coupling partners. This reagent enables efficient C–C bond formation under standard Suzuki, Stille, or Negishi conditions, offering predictable reactivity and straightforward purification, making it a reliable choice for complex molecule synthesis.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3265
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Class : 8
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Packing Group : Ⅱ
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Hazard Statements : H290-H314
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Precautionary Statements : P234-P260-P264-P280-P301+P330+P331-P304+P340-P363-P390-P405-P406-P501
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Lot numbers can be found on the outside label of a product: