H-Tyr(H2PO3)-OH

Name: H-Tyr(H2PO3)-OH
Brand: ChemScene
Availability: InStock
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CAS No. 21820-51-9
Cat. No. CS-W012494
Purity≥98%
MDL No.MFCD00002603

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Description

Ethylenediaminetetraacetic acid (EDTA) is a substituted diamine and a versatile compound in household with industrial applications. EDTA chelates metal divalent cations like calcium, magnesium, zinc, copper, manganese by forming metal-EDTA complexes. It finds its application in cleaning products and detergent formulations. In paper and pulp industries, EDTA reduces the adverse effect of metal ions on bleaching. It functions as an antibacterial agent by removing calcium and magnesium divalent cations from the outer membrane and causes loss of lipopolysaccharide from the membrane, making the bacteria susceptible to bactericidal agents. Free EDTA has adverse effect on reproduction and development in mammals. EDTA can chelate ions from deposits that contribute to atherosclerosis, cancers and heart diseases. It can help to overcome cell membrane injury by reducing radical reactions and oxidation processes. It binds to calcium and reduces the risk of hypercalcinemia in cancer patients. Transmembrane ammonium EDTA gradient method aids in drug delivery, increasing drug retention and efficacy of therapeutics and lowers the cytotoxicity levels.EDTA has been used:as a medium supplement in embryo culture using synthetic oviduct fluid culture 1 (SOFC1) mediumin incubation of EpCAM+ cells with fluorescein isothiocyanate (FITC) conjugated antibody for cell sorting analysisin pre-treatment of single cell suspension of dendritic cells from spleen for cell sorting with magnetic beads

Application

H-Tyr(H2PO3)-OH serves as a phosphorylated tyrosine building block for peptide synthesis, enabling site-specific incorporation of phosphotyrosine motifs. The H₂PO₃ group provides a stable, bioisosteric mimic of physiological phosphate, facilitating studies in kinase signaling pathways. Its bench-stable nature and compatibility with standard Fmoc-SPPS protocols simplify purification and integration into complex peptide sequences.

General Information

CAS No. 21820-51-9
Cat. No. CS-W012494
Purity ≥98%
MDL No. MFCD00002603
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₉H₁₂NO₆P
Molecular Weight 261.17
Synonym(s) None
SMILES O=C(O)[C@@H](N)CC1=CC=C(OP(O)(O)=O)C=C1

Computational Chemistry Data

TPSA 130.08
LogP 0.1125
H_Acceptors 4
H_Donors 4
Rotatable_Bonds 5

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Bioactive Molecules Peptides

Life Science Amino Acids and their Derivatives Tyrosine and derivatives

Chemical Biology Peptide Chemistry Amino Acid Derivatives

Biochemistry Biochemicals and Reagents Amino Acids Biologically-modified Amino Acids

Key Words

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H-Tyr(H2PO3)-OH

CAS No. 21820-51-9

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