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Structure of 219535-00-9
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2-Bromo-5-(trifluoromethyl)-1H-imidazole features a trifluoromethyl group that imparts strong electron-withdrawing character and enhanced metabolic stability, while the bromine substituent enables facile palladium-catalyzed cross-coupling reactions. This imidazole scaffold serves as a robust bioisostere in medicinal chemistry and provides a versatile handle for diversification in drug discovery and functional material design under standard conditions.
2-Bromo-5-(trifluoromethyl)-1H-imidazole serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions to construct biologically relevant heterocyclic scaffolds. The bromine atom facilitates efficient C–C and C–N bond formation, while the trifluoromethyl group enhances metabolic stability and lipophilicity. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for iterative synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: