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Structure of 288315-03-7
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This bench-stable difluorinated azetidine scaffold integrates a strained three-membered ring with dual fluorine substituents, delivering enhanced metabolic stability and modulated basicity. The hydrochloride salt form improves solubility and handling, enabling efficient incorporation into bioactive molecules for medicinal chemistry applications.
3,3-Difluoroazetidine (hydrochloride) serves as a conformationally constrained, bioisosteric building block for medicinal chemistry, enabling the introduction of enhanced metabolic stability and modulated polarity into drug candidates. The difluorinated azetidine ring exhibits robust bench stability, facilitates efficient coupling reactions, and functions effectively in standard amide bond formation and reductive amination protocols. Its compatibility with diverse functional groups and ease of purification make it a practical scaffold for constructing complex heterocyclic architectures in API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501
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Lot numbers can be found on the outside label of a product: