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Structure of 220227-98-5
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4-Hydroxy-3-(trifluoromethyl)benzaldehyde features a phenolic hydroxyl group ortho to a strongly electron-withdrawing trifluoromethyl substituent, enhancing its reactivity in electrophilic aromatic substitution. This bifunctional scaffold integrates readily into pharmaceutical intermediates and functional materials due to its balanced polarity and stability under standard conditions.
4-Hydroxy-3-(trifluoromethyl)benzaldehyde serves as a versatile building block for pharmaceutical and agrochemical synthesis, enabling direct incorporation of both phenolic and electron-withdrawing trifluoromethyl functionalities. Its aldehyde group facilitates efficient imine formation, reductive amination, and Ullmann-type coupling reactions, while the hydroxyl group supports orthogonal protection strategies. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for iterative synthetic workflows in medicinal chemistry and process development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: