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Structure of 22236-10-8
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4-(Difluoromethoxy)aniline features a difluoromethoxy group appended to an aromatic aniline scaffold, delivering enhanced metabolic stability and improved lipophilicity over conventional anilines. This electron-rich moiety enables efficient coupling in cross-coupling reactions and serves as a key building block in medicinal chemistry for targeted drug discovery pipelines.
4-(Difluoromethoxy)aniline serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its difluoromethoxy group imparts enhanced metabolic stability and modulated lipophilicity, while the aniline functionality facilitates straightforward coupling reactions and electrophilic substitution. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for iterative synthetic workflows in API development.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2810
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H301-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: