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Structure of 22246-02-2
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6-Chloro-3,4-dihydroisoquinolin-1(2H)-one is a bench-stable heterocyclic scaffold featuring a chlorine substituent at the 6-position and a lactam carbonyl at C1. This electron-deficient core integrates readily into medicinal chemistry campaigns, offering enhanced metabolic stability and favorable binding interactions in target-directed synthesis.
6-Chloro-3,4-dihydroisoquinolin-1(2H)-one serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive isoquinoline derivatives. Its electrophilic chlorine substituent facilitates nucleophilic substitution and palladium-catalyzed coupling reactions, while the lactam functionality offers hydrogen-bonding capacity and structural rigidity. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for iterative synthesis and scaffold diversification in drug discovery campaigns.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: