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Structure of 22282-65-1
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4-Iodo-2-methylpyridine features a strategically positioned iodine atom at the pyridine ring's 4-position, enabling efficient cross-coupling reactions. The ortho-methyl group enhances electronic modulation and provides steric differentiation, improving selectivity in transition metal-catalyzed transformations. This bench-stable derivative serves as a key intermediate in synthesizing functionalized heterocycles for medicinal chemistry and materials science applications.
4-Iodo-2-methylpyridine serves as a versatile building block in cross-coupling chemistry, enabling efficient access to substituted pyridines via palladium-catalyzed reactions. The iodide group provides high reactivity in Suzuki, Stille, and Negishi couplings, while the methyl substituent offers moderate electronic modulation. Bench-stable and readily purified by distillation, it functions effectively in late-stage functionalization and heterocyclic scaffold construction for medicinal chemistry and materials applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: