Lot numbers can be found on the outside label of a product:
Rivaroxaban impurity 70
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CAS No. 22353-82-8
- Cat. No. CS-0157773
- Purity≥98%
- MDL No.MFCD01922226
*For research and further manufacturing use only, not for direct human use.
Structure of 22353-82-8
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General Information
- CAS No. 22353-82-8
- Cat. No. CS-0157773
- Purity ≥98%
- MDL No. MFCD01922226
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₅H₄ClNOS
- Molecular Weight 161.60
- Synonym(s) Rivaroxaban impurity 115
- SMILES O=C(N)C=1SC(Cl)=CC1
Description
5-Chlorothiophene-2-carboxamide features a thiophene core functionalized with chlorine and carboxamide groups, offering enhanced electronic properties for heterocyclic synthesis. This bench-stable compound integrates readily into pharmaceutical intermediates and materials science applications, leveraging its planar structure and polar functionality.
Application
5-Chlorothiophene-2-carboxamide serves as a versatile building block in medicinal chemistry and materials science, enabling efficient access to functionalized thiophene scaffolds. Its stability under standard reaction conditions and compatibility with palladium-catalyzed cross-coupling reactions facilitate the construction of complex heterocyclic architectures. The carboxamide group provides a handle for further derivatization, while the chloro substituent supports direct nucleophilic substitution or transition-metal-mediated transformations.
Synthesis
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Route1
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In-stock
35475-03-7 - ~76%
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In-stock
22353-82-8
References
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Millennium Pharmaceuticals, Inc. Patent: US2011/152530 A1, 2011 ; Location in patent: Page/Page column 18 ;
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Route2
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In-stock
125712-84-7 - ~73%
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In-stock
22353-82-8
References
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Cao, Liping; Ding, Jiaoyang; Gao, Meng; Wang, Zihua; Li, Juan; Wu, Anxin Organic Letters, 2009 , vol. 11, # 17 p. 3810 - 3813
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Route3
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6310-09-4 - ~79%
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In-stock
22353-82-8
References
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Cao, Liping; Ding, Jiaoyang; Gao, Meng; Wang, Zihua; Li, Juan; Wu, Anxin Organic Letters, 2009 , vol. 11, # 17 p. 3810 - 3813
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H312-H332
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Precautionary Statements : P264-P270-P302+P352-P304+P340-P330-P501
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Quality Control
Computational Chemistry Data
- TPSA 43.09
- LogP 1.5004
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
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