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CS-W001157 4
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Trimethoxy(pentafluorophenyl)silane

  • CAS No. 223668-64-2

  • Cat. No. CS-0121750
  • Molecule weightNone
  • Purity≥95%
  • MDL No.MFCD04039205

*For research and further manufacturing use only, not for direct human use.

Trimethoxy(pentafluorophenyl)silane|CS-0121750

Structure of 223668-64-2

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General Information

  • CAS No. 223668-64-2
  • Cat. No. CS-0121750
  • Purity ≥95%
  • MDL No. MFCD04039205
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₉F₅O₃Si
  • Molecular Weight None
  • Synonym(s) benzene, 1,2,3,4,5-pentafluoro-6-(trimethoxysilyl)-
  • SMILES FC1=C(F)C(F)=C(F)C(F)=C1[Si](OC)(OC)OC

Description

Trimethoxy(pentafluorophenyl)silane features a pentafluorophenyl group attached to a silicon center bearing three methoxy groups. This combination delivers high reactivity in hydrosilylation and coupling reactions, with enhanced stability under standard conditions. The electron-deficient aromatic ring facilitates efficient cross-coupling processes, while the methoxy substituents enable controlled hydrolysis for surface functionalization.

Application

Trimethoxy(pentafluorophenyl)silane serves as a robust silylating agent for hydroxyl and amine functionalities, enabling efficient protection and functional group manipulation. Its pentafluorophenyl moiety enhances leaving-group stability and reactivity in nucleophilic substitution, facilitating clean coupling reactions. The trimethoxy groups provide high solubility and stability under standard bench conditions, while the fluorinated aryl unit offers excellent functional group tolerance. This compound functions effectively in peptide synthesis, oligonucleotide modification, and polymer functionalization workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H227-H315-H319
Precautionary Statements : P210-P264-P280-P302+P352-P362+P364-P370+P378-P403-P501

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Computational Chemistry Data

  • TPSA   27.69
  • LogP   1.4672
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   4

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