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Structure of 223919-54-8
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(E)-2-(4-Chlorostyryl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is a bench-stable boronate reagent featuring a stereodefined (E)-vinyl chloride moiety. This configuration enables efficient palladium-catalyzed cross-coupling reactions with aryl halides and triflates. The tetramethyl-substituted dioxaborolane ring enhances stability and solubility in organic solvents. Designed for use in late-stage functionalization and diversity-oriented synthesis, the compound delivers high yields under mild reaction conditions.
(E)-2-(4-Chlorostyryl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane serves as a stable, bench-ready boronate building block for palladium-catalyzed cross-coupling reactions. The (E)-configured vinylboronate enables efficient Suzuki-Miyaura coupling with aryl halides and pseudohalides, offering high regioselectivity and functional group tolerance. Its tetramethyl-substituted dioxaborolane ring enhances stability and simplifies purification, making it ideal for constructing biaryl scaffolds in medicinal chemistry and materials science applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302
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Precautionary Statements : P264-P270-P330-P501
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Lot numbers can be found on the outside label of a product: