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Structure of 22468-26-4
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4-Hydroxypyridine-2-carboxylic acid features a dual functional group architecture combining a phenolic hydroxyl and a carboxylic acid at ortho positions on a pyridine ring. This arrangement enables strong intramolecular hydrogen bonding, enhancing stability and influencing coordination behavior in metal complexes. The molecule serves as a versatile scaffold for ligand design in catalysis and pharmaceutical development.
4-Hydroxypyridine-2-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through established coupling and cyclization protocols. Its dual functionality—phenolic hydroxyl and carboxylic acid—facilitates orthogonal derivatization, enhances solubility, and supports metal chelation in transition-metal-catalyzed transformations. The compound exhibits good bench stability and is readily purified by recrystallization or column chromatography, making it suitable for scalable synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: