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CS-W001157 4
Total: USD 88.00

4-Hydroxypyridine-2,6-dicarboxylic acid

  • CAS No. 499-51-4

  • Cat. No. CS-0166907
  • Purity≥95%
  • MDL No.MFCD00066478
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

4-Hydroxypyridine-2,6-dicarboxylic acid|CS-0166907

Structure of 499-51-4

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Description

4-Hydroxypyridine-2,6-dicarboxylic acid features a rigid pyridine core functionalized with two carboxylic acid groups and a hydroxyl moiety, enabling strong metal chelation and hydrogen bonding. This arrangement supports coordination in supramolecular architectures and catalytic systems, particularly under physiological conditions. The molecule exhibits enhanced solubility and stability in aqueous environments, facilitating use in bioactive compound synthesis and ligand design.

Application

4-Hydroxypyridine-2,6-dicarboxylic acid serves as a versatile building block in medicinal chemistry and catalytic synthesis, enabling the construction of bioactive heterocyclic scaffolds. Its orthogonal functional groups—phenolic hydroxyl and two carboxylic acids—facilitate selective derivatization, metal coordination, and solid-phase synthesis. The compound exhibits good bench stability and compatibility with standard purification techniques, making it suitable for use in multi-step syntheses and process development workflows.

General Information

  • CAS No. 499-51-4
  • Cat. No. CS-0166907
  • Purity ≥95%
  • MDL No. MFCD00066478
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅NO₅
  • Molecular Weight None
  • Synonym(s) Helidaminic acid
  • SMILES O=C(C1=NC(C(O)=O)=CC(O)=C1)O

Computational Chemistry Data

  • TPSA   107.72
  • LogP   0.1836
  • H_Acceptors   4
  • H_Donors   3
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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