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*For research and further manufacturing use only, not for direct human use.
Structure of 2250-53-5
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5-(Trifluoromethyl)-1H-indazol-3-amine delivers a potent electron-deficient heterocyclic scaffold featuring a trifluoromethyl group at the 5-position and an amino function at C3. This configuration enables direct integration into kinase inhibitors and bioactive conjugates, offering enhanced metabolic stability and improved membrane permeability in drug discovery campaigns.
5-(Trifluoromethyl)-1H-indazol-3-amine serves as a versatile building block for medicinal chemistry and agrochemical research, enabling efficient construction of bioactive heterocycles. Its trifluoromethyl group enhances metabolic stability and lipophilicity, while the primary amine facilitates direct functionalization in Suzuki-Miyaura couplings, amidations, and electrophilic substitutions. The compound exhibits excellent bench stability and is readily purified by recrystallization or flash chromatography, making it well-suited for high-throughput synthesis workflows.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2811
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Class : 6.1
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Packing Group : Ⅱ
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Hazard Statements : H301+H311+H331
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Precautionary Statements : P260-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361-P363-P405-P501
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Lot numbers can be found on the outside label of a product: