7-Chloro-6-fluoro-1-(2-isopropyl-4-methyl-3-pyridyl)pyrido[2,3-d]pyrimidine-2,4-dione

Name: 7-Chloro-6-fluoro-1-(2-isopropyl-4-methyl-3-pyridyl)pyrido[2,3-d]pyrimidine-2,4-dione
Brand: ChemScene
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CAS No. 2252403-82-8
Cat. No. CS-0102389
Purity≥98%
MDL No.MFCD32068506

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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7-Chloro-6-fluoro-1-(2-isopropyl-4-methyl-3-pyridyl)pyrido[2,3-d]pyrimidine-2,4-dione|CS-0102389

Structure of 2252403-82-8

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General Information

CAS No. 2252403-82-8
Cat. No. CS-0102389
Purity ≥98%
MDL No. MFCD32068506
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₆H₁₄ClFN₄O₂
Molecular Weight 348.76
Synonym(s) None
SMILES O=C1N(C2=C(C)C=CN=C2C(C)C)C3=NC(Cl)=C(F)C=C3C(N1)=O

Description

This pyrido[2,3-d]pyrimidine-dione scaffold features a chloro-fluoro substitution pattern that enhances electron-withdrawal and metabolic stability. The 2-isopropyl-4-methylpyridin-3-yl group provides steric bulk and lipophilic character, improving target engagement in kinase inhibition workflows under standard conditions.

Application

7-Chloro-6-fluoro-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione serves as a versatile heterocyclic building block for medicinal chemistry campaigns, enabling efficient access to pyrido[2,3-d]pyrimidine-based scaffolds. Its well-defined functional group pattern—comprising chloro, fluoro, and methyl-substituted pyridine moieties—supports robust coupling reactions and facilitates downstream derivatization. The compound exhibits excellent bench stability and is amenable to standard purification techniques, making it suitable for scalable synthesis and structure-activity studies.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 80.64
LogP 2.69332
H_Acceptors 5
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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7-Chloro-6-fluoro-1-(2-isopropyl-4-methyl-3-pyridyl)pyrido[2,3-d]pyrimidine-2,4-dione

CAS No. 2252403-82-8

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