2-Chloro-5-methylpyrimidine

Name: 2-Chloro-5-methylpyrimidine
Brand: ChemScene
Availability: InStock
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CAS No. 22536-61-4
Cat. No. CS-D0889
Purity≥98%
MDL No.MFCD09260903

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 22536-61-4

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Description

2-Chloro-5-methylpyrimidine is a bench-stable heterocyclic building block featuring a chlorinated pyrimidine core with a methyl group at the 5-position. This electron-deficient scaffold enables efficient coupling reactions, particularly in palladium-catalyzed cross-couplings, where the chlorine serves as an excellent leaving group. The methyl substituent enhances solubility and modulates reactivity, facilitating incorporation into pharmaceutical intermediates and functional materials.

Application

2-Chloro-5-methylpyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient late-stage functionalization via palladium-catalyzed cross-coupling reactions. Its chloro group exhibits high reactivity toward nucleophiles under mild conditions, while the methyl substituent enhances solubility and modulates electronic properties. The compound demonstrates excellent bench stability and compatibility with diverse functional groups, facilitating straightforward purification and integration into complex molecular architectures.

General Information

CAS No. 22536-61-4
Cat. No. CS-D0889
Purity ≥98%
MDL No. MFCD09260903
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₅ClN₂
Molecular Weight 128.56
Synonym(s) Pyrimidine, 2-chloro-5-methyl- (8CI,9CI)
SMILES ClC1=NC=C(C)C=N1

Computational Chemistry Data

TPSA 25.78
LogP 1.43842
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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2-Chloro-5-methylpyrimidine

CAS No. 22536-61-4

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