Lot numbers can be found on the outside label of a product:
2-Chloro-4-methoxy-6-methylpyrimidine
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CAS No. 22536-64-7
- Cat. No. CS-0045695
- Purity≥96%
- MDL No.MFCD08689881
*For research and further manufacturing use only, not for direct human use.
Structure of 22536-64-7
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General Information
- CAS No. 22536-64-7
- Cat. No. CS-0045695
- Purity ≥96%
- MDL No. MFCD08689881
- Storage -20°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₆H₇ClN₂O
- Molecular Weight 158.59
- Synonym(s) 2-Chlor-4-methoxy-6-methyl-pyrimidin
- SMILES COC1=NC(Cl)=NC(C)=C1
Description
2-Chloro-4-methoxy-6-methylpyrimidine features a strategically positioned chloro group and methoxy substituent on a pyrimidine core, enabling selective functionalization in medicinal chemistry. The methyl group enhances lipophilicity while maintaining synthetic tractability under standard conditions. This scaffold serves as a key building block for kinase inhibitors and agrochemical intermediates.
Application
2-Chloro-4-methoxy-6-methylpyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds. Its chloro group facilitates nucleophilic substitution reactions, while the methoxy and methyl substituents provide orthogonal functional handles for further derivatization. The compound exhibits good bench stability and is compatible with standard coupling protocols, making it valuable for the synthesis of kinase inhibitors and other bioactive heterocycles.
Synthesis
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Route1
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In-stock
7749-47-5 - ~%
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In-stock
22536-64-7
References
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Yakugaku Zasshi, , vol. 73, p. 598,600 Chem.Abstr., , p. 9362 Bulletin des Societes Chimiques Belges, , vol. 68, p. 30,55
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Route2
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In-stock
5424-21-5 -
124-41-4 - ~%
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In-stock
22536-64-7
References
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Bulletin des Societes Chimiques Belges, , vol. 68, p. 30,55
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Route3
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In-stock
5600-21-5 - ~%
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In-stock
22536-64-7
References
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Yakugaku Zasshi, , vol. 73, p. 598,600 Chem.Abstr., , p. 9362
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 35.01
- LogP 1.44702
- H_Acceptors 3
- H_Donors 0
- Rotatable_Bonds 1
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Key Words
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