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CS-W001157 4
Total: USD 88.00

2,5-Dichloropyrimidine

  • CAS No. 22536-67-0

  • Cat. No. CS-M2651
  • Purity≥97%
  • MDL No.MFCD00673131

*For research and further manufacturing use only, not for direct human use.

2,5-Dichloropyrimidine|CS-M2651

Structure of 22536-67-0

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General Information

  • CAS No. 22536-67-0
  • Cat. No. CS-M2651
  • Purity ≥97%
  • MDL No. MFCD00673131
  • Storage RT, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₂Cl₂N₂
  • Molecular Weight 148.98
  • Synonym(s) None
  • SMILES ClC1=NC=C(Cl)C=N1

Description

2,5-Dichloropyrimidine serves as a pivotal building block in medicinal chemistry and materials synthesis. This electron-deficient heterocycle features two chlorine substituents at the 2- and 5-positions, enabling efficient nucleophilic substitution reactions. The molecule exhibits high reactivity under mild conditions and maintains bench-stability, facilitating its integration into diverse molecular architectures.

Application

2,5-Dichloropyrimidine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient functionalization at C2 and C5 positions via nucleophilic substitution. Its high reactivity facilitates the construction of substituted pyrimidines under mild conditions, with excellent functional group tolerance and bench stability. Widely used in the synthesis of kinase inhibitors and heterocyclic APIs, it functions as a key intermediate in cross-coupling and amine displacement reactions.

Synthesis

  • Route1

    References

    • WO2008/85316 A1, ; Page/Page column 96 ; WO 2008/085316 A1
  • Route2

    References

    • WO2006/7693 A1, ; Page/Page column 64; 65 ;
  • Route3

    References

    • US2477409 , ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3077
Class : 9
Packing Group : Ⅲ
Hazard Statements : H302-H318
Precautionary Statements : P264-P270-P280-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   1.7834
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   0

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