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Potassium ((1-(tert-butoxycarbonyl)azetidin-3-yl)methyl)trifluoroborate

  • CAS No. 2254447-10-2

  • Cat. No. CS-0659007
  • Purity≥98%
  • MDL No.MFCD18712403

*For research and further manufacturing use only, not for direct human use.

Potassium ((1-(tert-butoxycarbonyl)azetidin-3-yl)methyl)trifluoroborate|CS-0659007

Structure of 2254447-10-2

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General Information

  • CAS No. 2254447-10-2
  • Cat. No. CS-0659007
  • Purity ≥98%
  • MDL No. MFCD18712403
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₆BF₃KNO₂
  • Molecular Weight 277.13
  • Synonym(s) None
  • SMILES [B-](CC1CN(C1)C(=O)OC(C)(C)C)(F)(F)F.[K+]

Description

Potassium ((1-(tert-butoxycarbonyl)azetidin-3-yl)methyl)trifluoroborate features a stable trifluoroborate moiety integrated into a protected azetidine scaffold, enabling direct cross-coupling without prior activation. This bench-stable reagent facilitates efficient incorporation of functionalized azetidinyl units into complex molecular architectures under standard Suzuki-Miyaura conditions.

Application

Potassium ((1-(tert-butoxycarbonyl)azetidin-3-yl)methyl)trifluoroborate serves as a stable, bench-friendly boronate building block for Suzuki-Miyaura coupling reactions. The Boc-protected azetidine moiety enables direct incorporation into complex scaffolds with high functional group tolerance and predictable reactivity. Its trifluoroborate salt enhances solubility and stability compared to traditional boronic acids, facilitating efficient cross-coupling in diverse reaction conditions.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅱ
Hazard Statements : H290-H314
Precautionary Statements : P234-P260-P264-P280-P301+P330+P331-P304+P340-P363-P390-P405-P406-P501

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Computational Chemistry Data

  • TPSA   29.54
  • LogP   -0.2953
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

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