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Structure of 66684-58-0
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1,2,3-Trifluoro-5-nitrobenzene features a highly electron-deficient aromatic ring due to the synergistic effect of three fluorine atoms and a para-nitro group. This combination enhances reactivity in nucleophilic aromatic substitution, enabling efficient coupling under mild conditions. The molecule exhibits excellent bench stability and moisture tolerance, simplifying handling in synthetic workflows.
1,2,3-Trifluoro-5-nitrobenzene serves as a versatile building block in medicinal chemistry and materials science, enabling direct electrophilic substitution or transition-metal-catalyzed coupling reactions. The electron-deficient aromatic core exhibits enhanced reactivity in Suzuki-Miyaura and Buchwald-Hartwig couplings, while the nitro group provides a handle for selective reduction or further functionalization. Bench-stable and compatible with common protecting groups, it facilitates efficient synthesis of fluorinated heterocycles and advanced pharmaceutical intermediates.
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GHS Pictogram :
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GHS No : GHS06
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Signal Word : Danger
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UN#: 2810
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H227-H300
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Precautionary Statements : P210-P264-P270-P280-P330-P370+P378-P405-P501
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Lot numbers can be found on the outside label of a product: