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Structure of 226070-47-9
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tert-Butyl 5-hydroxyisoindoline-2-carboxylate features a hydroxylated isoindoline core with a bench-stable tert-butyl ester, enabling direct functionalization at the 5-position. The electron-rich aromatic system facilitates transition-metal-catalyzed coupling reactions, while the hydroxyl group offers a handle for selective derivatization. This scaffold serves as a key intermediate in bioactive molecule synthesis.
tert-Butyl 5-hydroxyisoindoline-2-carboxylate serves as a versatile building block for isoindoline-based scaffolds in medicinal chemistry. The hydroxyl group enables direct functionalization via esterification, ether formation, or oxidation to ketone intermediates. Its tert-butyl carbamate protection offers stability under basic conditions and facile removal during late-stage deprotection. This compound functions reliably in Pd-catalyzed cross-coupling and reductive amination workflows, providing access to diverse heterocyclic architectures with predictable reactivity.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: