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Structure of 2296-23-3
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4-Hydroxy-3-iodobenzonitrile features a hydroxyl group flanked by iodine and nitrile functionalities on a benzene ring, enabling selective coupling reactions. This electron-deficient aryl iodide integrates readily into cross-coupling processes, offering high stability under standard conditions for synthetic applications in medicinal chemistry and materials science.
4-Hydroxy-3-iodobenzonitrile serves as a versatile building block for Suzuki-Miyaura and Sonogashira coupling reactions, enabling efficient access to biaryl and alkenylated scaffolds. The ortho-iodo group exhibits high reactivity under palladium catalysis, while the phenolic hydroxyl and nitrile functionalities offer orthogonal handles for further derivatization. Bench-stable and amenable to purification via recrystallization, it functions effectively in multi-step synthesis of functionalized heterocycles and medicinal chemistry intermediates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: