1-(2-Amino-5-fluorophenyl)ethanone

Name: 1-(2-Amino-5-fluorophenyl)ethanone
Brand: ChemScene
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CAS No. 2343-25-1
Cat. No. CS-W005413
Purity≥97%
MDL No.MFCD09835333

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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1-(2-Amino-5-fluorophenyl)ethanone|CS-W005413

Structure of 2343-25-1

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Description

1-(2-Amino-5-fluorophenyl)ethanone features a fluorinated aromatic ring paired with a reactive acetamido group, enabling direct integration into pharmaceutical scaffolds. The para-fluoro substitution enhances metabolic stability, while the amino functionality supports facile derivatization under standard conditions. This compound serves as a key intermediate in the synthesis of bioactive molecules targeting neurological and oncological pathways.

Application

1-(2-Amino-5-fluorophenyl)ethanone serves as a versatile building block for the synthesis of fluorinated aromatic scaffolds. Its ortho-amino and fluoro substituents enable directed metalation and facilitate transition-metal-catalyzed coupling reactions. The ketone functionality supports nucleophilic additions and reductive transformations, offering reliable access to substituted anilines and heterocyclic intermediates in medicinal chemistry workflows. Bench-stable and amenable to standard purification methods, it functions effectively in multi-step syntheses requiring functional group compatibility.

General Information

CAS No. 2343-25-1
Cat. No. CS-W005413
Purity ≥97%
MDL No. MFCD09835333
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₈FNO
Molecular Weight 153.15
Synonym(s) Ethanone, 1-(2-amino-5-fluorophenyl)-
SMILES CC(=O)C1=C(N)C=CC(F)=C1

Computational Chemistry Data

TPSA 43.09
LogP 1.6105
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Ketone

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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1-(2-Amino-5-fluorophenyl)ethanone

CAS No. 2343-25-1

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