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CS-W001157 4
Total: USD 88.00

(3-Chloropropyl)trimethylsilane

  • CAS No. 2344-83-4

  • Cat. No. CS-0199377
  • Molecule weight150.72
  • Purity≥98%
  • MDL No.MFCD00045299

*For research and further manufacturing use only, not for direct human use.

(3-Chloropropyl)trimethylsilane|CS-0199377

Structure of 2344-83-4

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General Information

  • CAS No. 2344-83-4
  • Cat. No. CS-0199377
  • Purity ≥98%
  • MDL No. MFCD00045299
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₅ClSi
  • Molecular Weight 150.72
  • Synonym(s) Chloropropyldiphenylmethylsilane
  • SMILES C[Si](C)(C)CCCCl

Description

(3-Chloropropyl)trimethylsilane features a reactive chloropropyl chain tethered to a stable trimethylsilyl group, enabling efficient silicon-directed functionalization. This bench-stable reagent integrates readily into cross-coupling and grafting workflows, offering reliable anchoring for surface modification and polymer synthesis under standard conditions.

Application

(3-Chloropropyl)trimethylsilane serves as a versatile silyl-protected chloroalkyl building block, enabling reliable introduction of functionalized alkyl chains in synthesis. Its stable trimethylsilyl group facilitates handling and purification, while the terminal chloride supports nucleophilic substitution reactions with amines, thiols, and heterocycles under mild conditions. Functions as a key intermediate in constructing bioactive scaffolds and polymer linkers.

Synthesis

  • Route1
    • null|null
      7787-93-1
    • null|null
      75-16-1
    • ~%
    • In-stock
      (3-Chloropropyl)trimethylsilane|CS-0199377
      2344-83-4

    References

    • Journal of the American Chemical Society, , vol. 82, p. 3601 - 3604
  • Route2
    • null|null
      5089-70-3
    • null|null
      917-54-4
    • ~57%
    • In-stock
      (3-Chloropropyl)trimethylsilane|CS-0199377
      2344-83-4

    References

    • Hu, Chunye; He, Ji-Gang; O'Brien, D. H.; Irgolic, K. J. Journal of Organometallic Chemistry, 1984 , vol. 268, # 1 p. 31 - 38
  • Route3
    • null|null
      7787-93-1
    • ~%
    • In-stock
      (3-Chloropropyl)trimethylsilane|CS-0199377
      2344-83-4

    References

    • Journal of the American Chemical Society, , vol. 79, p. 2764,2768 Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , p. 85,88;engl.Ausg.S.76,78

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H226-H315-H319-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   0
  • LogP   2.9535
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   3

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