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Structure of 2375-96-4
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1,4-Bis(trifluoromethyl)-2,5-dibromobenzene features two trifluoromethyl groups flanking a dibrominated aromatic core, delivering enhanced electron-withdrawing character and stability. This configuration enables efficient coupling in cross-coupling reactions, particularly in Pd-catalyzed transformations. The molecule exhibits excellent bench stability and tolerance to moisture, simplifying handling in synthetic workflows.
1,4-Bis(trifluoromethyl)-2,5-dibromobenzene serves as a versatile building block for the synthesis of fluorinated aromatic scaffolds. Its orthogonal halogenation pattern enables sequential cross-coupling reactions, facilitating the construction of complex biaryl and heterocyclic architectures. The trifluoromethyl groups enhance metabolic stability and lipophilicity, making it valuable in medicinal chemistry lead optimization. Bench-stable and amenable to purification via flash chromatography, it functions reliably in Pd-catalyzed coupling protocols under standard conditions.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: