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Structure of 645-83-0
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This sulfonate-containing carboxylic acid features a methylsulfonyl group that enhances solubility and metabolic stability. The rigid, electron-withdrawing moiety integrates readily into bioactive scaffolds, offering improved polarity and reduced lipophilicity in drug discovery applications.
3-(Methylsulfonyl)propanoic acid serves as a versatile building block in medicinal chemistry, enabling the introduction of a polar, metabolically stable sulfone group adjacent to a carboxylic acid. Its well-defined reactivity facilitates amide bond formation and conjugation strategies, while the methylsulfonyl moiety enhances solubility and provides orthogonal functionalization potential. The compound exhibits excellent bench stability and is compatible with standard purification methods, making it suitable for use in high-throughput synthesis and API intermediate development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: