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Structure of 2401-21-0
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1,2-Dichloro-3-iodobenzene is a halogenated aromatic compound featuring complementary chlorine and iodine substituents at adjacent positions on the benzene ring. This configuration enables selective cross-coupling reactions in transition-metal-catalyzed processes, particularly in palladium-mediated C–C bond formation. The molecule's electron-deficient nature enhances reactivity in Suzuki-Miyaura and Stille couplings while maintaining stability under standard reaction conditions.
1,2-Dichloro-3-iodobenzene serves as a versatile building block in cross-coupling chemistry, enabling the construction of substituted biaryls and heterocycles under palladium-catalyzed conditions. The ortho-dichloro substitution pattern provides enhanced stability and facilitates selective functionalization, while the iodine moiety offers high reactivity in Suzuki, Stille, and Negishi couplings. Its bench-stable nature and compatibility with diverse reaction conditions make it ideal for iterative synthesis workflows in medicinal chemistry and materials science.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: