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CS-W001157 4
Total: USD 88.00

4-Cyanopiperidine hydrochloride

  • CAS No. 240401-22-3

  • Cat. No. CS-0019876
  • Molecule weight146.62
  • Purity≥95%
  • MDL No.MFCD09037930

*For research and further manufacturing use only, not for direct human use.

4-Cyanopiperidine hydrochloride|CS-0019876

Structure of 240401-22-3

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General Information

  • CAS No. 240401-22-3
  • Cat. No. CS-0019876
  • Purity ≥95%
  • MDL No. MFCD09037930
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁ClN₂
  • Molecular Weight 146.62
  • Synonym(s) Piperidine-4-carbonitrile hydrochloride
  • SMILES N#CC1CCNCC1.[H]Cl

Description

4-Cyanopiperidine hydrochloride offers a stable, moisture-tolerant platform for medicinal chemistry applications. The electron-deficient nitrile group enhances target engagement in kinase inhibition studies, while the protonated piperidine ring ensures solubility and bioavailability. This salt form facilitates handling and purification under standard bench conditions.

Application

4-Cyanopiperidine (hydrochloride) serves as a versatile building block in medicinal chemistry, enabling efficient access to nitrogen-containing heterocycles and bioactive scaffolds. The nitrile group provides a handle for nucleophilic transformations and downstream functionalization, while the piperidine core offers favorable physicochemical properties for drug-like molecules. Bench-stable and readily purified, it functions effectively in standard coupling and cyclization protocols.

Synthesis

  • Route1
    • In-stock
      N-Methylpyrrolidone|CS-0017258
      872-50-4
    • null|null
      178308-63-9
    • ~%
    • In-stock
      4-Cyanopiperidine hydrochloride|CS-0019876
      240401-22-3

    References

    • US6498159 B1, ;
  • Route2

    References

    • WO2008/132502 A1, ; Page/Page column 96 ; WO 2008/132502 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   35.82
  • LogP   0.93138
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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