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N,N-Diethyl-2-phenylacetamide

  • CAS No. 2431-96-1

  • Cat. No. CS-0152036
  • Purity≥95%
  • MDL No.MFCD00192031

*For research and further manufacturing use only, not for direct human use.

N,N-Diethyl-2-phenylacetamide|CS-0152036

Structure of 2431-96-1

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General Information

  • CAS No. 2431-96-1
  • Cat. No. CS-0152036
  • Purity ≥95%
  • MDL No. MFCD00192031
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₇NO
  • Molecular Weight 191.27
  • Synonym(s) phenyl-n,n-diethylacetamide
  • SMILES CCN(CC)C(=O)CC1=CC=CC=C1

Description

N,N-Diethyl-2-phenylacetamide features a benzyl-amide scaffold with two ethyl groups on the nitrogen, conferring enhanced lipophilicity and metabolic stability. This structural configuration supports efficient integration into complex synthetic intermediates for pharmaceutical applications, particularly in CNS-targeted drug development.

Application

N,N-Diethyl-2-phenylacetamide serves as a stable, bench-accessible amide building block for synthetic applications requiring moderate lipophilicity and functional group tolerance. It functions as a versatile precursor in the construction of heterocyclic scaffolds and enables straightforward derivatization via deprotonation or transition-metal-catalyzed coupling reactions. Its structural motif supports integration into medicinal chemistry campaigns targeting CNS-penetrant molecules, offering predictable reactivity and ease of purification in standard organic workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   20.31
  • LogP   2.0975
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   4

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