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CS-W001157 4
Total: USD 88.00

1,2,4,5-Tetramethoxybenzene

  • CAS No. 2441-46-5

  • Cat. No. CS-0199380
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1,2,4,5-Tetramethoxybenzene|CS-0199380

Structure of 2441-46-5

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General Information

  • CAS No. 2441-46-5
  • Cat. No. CS-0199380
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₄O₄
  • Molecular Weight 198.22
  • Synonym(s) None
  • SMILES COC1=CC(=C(C=C1OC)OC)OC

Description

1,2,4,5-Tetramethoxybenzene features a highly electron-rich aromatic core stabilized by four methoxy groups in a symmetric arrangement. This configuration enhances solubility in organic solvents and supports stability under standard bench conditions. The compound serves as a key scaffold for synthesizing functionalized dyes, photoactive materials, and molecular building blocks in organic electronics.

Application

1,2,4,5-Tetramethoxybenzene serves as a versatile building block in synthetic organic chemistry, enabling efficient access to functionalized aromatic systems. Its four methoxy groups provide strong electron-donating character, facilitating electrophilic substitution and serving as reliable handles for further derivatization. The compound exhibits excellent bench stability and simplifies purification due to high crystallinity, making it well-suited for use in medicinal chemistry lead optimization and heterocyclic scaffold construction.

Synthesis

  • Route1
    • 2,4,5-trimethoxyphenol|CS-0036238
      20491-91-2
    • null|null
      74-88-4
    • ~95%
    • In-stock
      1,2,4,5-Tetramethoxybenzene|CS-0199380
      2441-46-5

    References

    • ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AN ON BEHALF OF ARIZONA STATE UNIVERSITY; MADATHIL, Manikandadas, Mathilakathu; KHDOUR, Omar; HECHT, Sidney Patent: WO2014/59158 A1, 2014 ; Location in patent: Page/Page column 34 ;
  • Route2
    • In-stock
      2,5-DMBQ|CS-0182620
      3117-03-1
    • null|null
      74-88-4
    • ~95%
    • In-stock
      1,2,4,5-Tetramethoxybenzene|CS-0199380
      2441-46-5

    References

    • Chen, Fanglei; Zhang, Guiping; Hong, Zebin; Lin, Zhonghui; Lei, Min; Huang, Mingdong; Hu, Lihong Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 10 p. 2379 - 2382
  • Route3
    • 2,5-Dimethoxybenzene-1,4-diol|CS-0942648
      13239-13-9
    • null|null
      77-78-1
    • ~81%
    • In-stock
      1,2,4,5-Tetramethoxybenzene|CS-0199380
      2441-46-5

    References

    • Hanss, David; Walther, Mathieu E.; Wenger, Oliver S. Chemical Communications, 2010 , vol. 46, # 37 p. 7034 - 7036

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   36.92
  • LogP   1.721
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   4

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