CRBN ligand-547

Name: CRBN ligand-547
Brand: ChemScene
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CAS No. 2446913-88-6
Cat. No. CS-0650756
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 2446913-88-6

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Description

This dihydropyrimidinone integrates a brominated indazolyl moiety, offering a robust scaffold for medicinal chemistry. The electron-deficient pyrimidinedione core pairs with the sterically accessible bromo-substituted indazole, enabling efficient cross-coupling and diversification. Bench-stable and moisture-tolerant, it streamlines synthesis in target-oriented discovery workflows.

Application

1-(6-Bromo-1-methyl-1H-indazol-3-yl)dihydropyrimidine-2,4(1H,3H)-dione serves as a versatile building block for the synthesis of heterocyclic scaffolds relevant to medicinal chemistry. The bromo group enables palladium-catalyzed cross-coupling reactions, while the dihydropyrimidinone core offers stability and functional group tolerance. Its bench-stable nature and compatibility with standard coupling protocols facilitate efficient access to complex molecular architectures in drug discovery workflows.

General Information

CAS No. 2446913-88-6
Cat. No. CS-0650756
Purity ≥98%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₁₁BrN₄O₂
Molecular Weight 323.15
Synonym(s) None
SMILES O=C1NC(=O)CCN1C2=NN(C=3C=C(Br)C=CC23)C

Computational Chemistry Data

TPSA 67.23
LogP 1.7821
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319
Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Amide

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic heterocycle compounds Indazole compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Other aliphatic heterocycles compounds

Life Science PROTAC Ligands for E3 Ligase

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

Drug Discovery Inflammation/Immunology IRAK4

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CRBN ligand-547

CAS No. 2446913-88-6

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