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Structure of 2467425-53-0
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Thalidomide-5-O-CH2-COOH features a strategically positioned carboxymethyl ester at the 5-oxygen site, enhancing solubility and enabling bioorthogonal conjugation. This derivative retains the core phthalimide scaffold while introducing a reactive handle for peptide coupling or surface immobilization, facilitating targeted delivery applications in chemical biology and medicinal chemistry workflows.
Thalidomide-5-O-CH₂-COOH serves as a functionalized derivative enabling targeted conjugation and prodrug strategies in medicinal chemistry. The pendant carboxylic acid group facilitates amide bond formation, esterification, or metal coordination, enhancing solubility and bioavailability. Its stability under standard reaction conditions supports reliable use in peptide coupling, antibody-drug conjugation, and scaffold diversification for immunomodulatory agents.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: