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CS-W001157 4
Total: USD 88.00

5,6,7-Trifluoro-1H-indole

  • CAS No. 247564-64-3

  • Cat. No. CS-0076847
  • Molecule weight171.12
  • Purity≥95%
  • MDL No.MFCD01863155

*For research and further manufacturing use only, not for direct human use.

5,6,7-Trifluoro-1H-indole|CS-0076847

Structure of 247564-64-3

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General Information

  • CAS No. 247564-64-3
  • Cat. No. CS-0076847
  • Purity ≥95%
  • MDL No. MFCD01863155
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₄F₃N
  • Molecular Weight 171.12
  • Synonym(s) None
  • SMILES FC1=C(F)C(F)=CC2=C1NC=C2

Description

5,6,7-Trifluoro-1H-indole features a fluorinated indole core with enhanced electron deficiency, enabling efficient coupling in cross-coupling reactions. The trifluoromethyl substitution pattern imparts improved metabolic stability and lipophilicity, making it valuable for medicinal chemistry applications. This bench-stable, moisture-tolerant heterocycle integrates readily into complex molecular architectures.

Application

5,6,7-Trifluoro-1H-indole serves as a valuable building block for fluorinated heterocycles, enabling direct functionalization at the indole core due to its electron-deficient aromatic system. The trifluorinated scaffold enhances metabolic stability and modulates electronic properties, facilitating incorporation into bioactive molecules. Its bench-stable nature and compatibility with standard coupling reactions make it suitable for medicinal chemistry campaigns and process-scale synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   15.79
  • LogP   2.5852
  • H_Acceptors   0
  • H_Donors   1
  • Rotatable_Bonds   0

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