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Structure of 271780-84-8
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6,7-Difluoro-1H-indole features a highly electron-deficient indole core due to the dual fluorine substituents at the 6 and 7 positions. This configuration enhances stability and directs electrophilic substitution selectively to the 3- and 4-positions. The molecule integrates readily into bioactive scaffolds and serves as a key building block in medicinal chemistry for modulating metabolic stability and membrane permeability.
6,7-Difluoro-1H-indole serves as a valuable building block for the synthesis of fluorinated heterocycles and bioactive molecules. Its electron-deficient aromatic core enables efficient transition-metal-catalyzed couplings and direct C–H functionalization. The difluoro substitution pattern enhances metabolic stability and modulates electronic properties, making it particularly useful in medicinal chemistry applications requiring improved pharmacokinetic profiles.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: