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CS-W001157 4
Total: USD 88.00

1-Bromo-2-butanol

  • CAS No. 2482-57-7

  • Cat. No. CS-0197080
  • Purity70+%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Bromo-2-butanol|CS-0197080

Structure of 2482-57-7

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General Information

  • CAS No. 2482-57-7
  • Cat. No. CS-0197080
  • Purity 70+%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₉BrO
  • Molecular Weight 153.02
  • Synonym(s) 1,2-Butane Bromohydrin (contains ca. 30% 2-Bromo-1-butanol)
  • SMILES CCC(CBr)O

Description

1-Bromo-2-butanol is a chiral bromohydrin featuring a reactive bromine atom adjacent to a hydroxyl group. This functional group arrangement enables selective nucleophilic substitution and elimination reactions under mild conditions. The molecule exhibits moderate stability and is compatible with common organic solvents, facilitating its use in synthetic transformations requiring stereocontrolled carbon–carbon bond formation.

Application

1-Bromo-2-butanol serves as a versatile bifunctional building block in synthetic organic chemistry, enabling efficient construction of cyclic ethers and stereoselective transformations. Its bromide and hydroxyl groups offer orthogonal reactivity, facilitating regioselective functionalization and serving as key intermediates in the synthesis of chiral synthons. The compound exhibits good bench stability and is compatible with standard purification techniques, making it well-suited for iterative synthesis workflows in medicinal chemistry and process development.

Synthesis

  • Route1
    • null|null
      558-13-4
    • In-stock
      Butane-1,2-diol|CS-0094102
      584-03-2
    • ~92%
    • In-stock
      1-Bromo-2-butanol|CS-0197080
      2482-57-7

    References

    • GlycoDesign Patent: US6048870 A1, 2000 ;
  • Route2
    • null|null
      106-88-7
    • ~96%
    • In-stock
      1-Bromo-2-butanol|CS-0197080
      2482-57-7

    References

    • Azizian, Javad; Shameli, Abolghasem; Balali, Ebrahim; Ghanbari, Mohammad Mehdei; Zomorodbakhsh, Shahab Oriental Journal of Chemistry, 2012 , vol. 28, # 3 p. 1361 - 1364
  • Route3
    • null|null
      106-98-9
    • ~%
    • In-stock
      1-Bromo-2-butanol|CS-0197080
      2482-57-7

    References

    • Dewey,C.S.; Bafford,R.A. Journal of Organic Chemistry, 1965 , vol. 30, p. 491 - 495

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H225
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P370+P378-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   1.1522
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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