1-Cbz-pyrrolidine

Name: 1-Cbz-pyrrolidine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 25070-74-0
Cat. No. CS-0156223
Purity≥97%
MDL No.MFCD18206031

HazMat Fee +

HazMat Fee

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 25070-74-0

Size

Price

Quantity

* Please select Quantity before adding items.

General Information

CAS No. 25070-74-0
Cat. No. CS-0156223
Purity ≥97%
MDL No. MFCD18206031
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₁₅NO₂
Molecular Weight 205.25
Synonym(s) 1-benzyloxycarbonylpyrrolidine
SMILES C1=CC=C(C=C1)COC(=O)N2CCCC2

Description

1-Cbz-pyrrolidine delivers a protected pyrrolidine scaffold with enhanced solubility and stability, enabling efficient incorporation into complex molecular architectures. This bench-stable reagent facilitates amine functionalization under mild conditions, streamlining synthetic workflows in medicinal chemistry and peptide derivatization.

Application

1-Cbz-pyrrolidine serves as a robust, bench-stable nitrogen protecting group for pyrrolidine derivatives, enabling selective functionalization in complex molecule synthesis. Its carbamate functionality facilitates orthogonal deprotection under mild hydrogenolysis conditions and exhibits excellent compatibility with diverse reaction environments. Widely employed in medicinal chemistry and API development, it functions as a key building block for heterocyclic scaffolds and peptide extensions.

Synthesis

Route1
- 123-75-1
- 501-53-1
- ~94%
- In-stock
  
  25070-74-0
References
- Myers, Eddie L.; De Vries, Johannes G.; Aggarwal, Varinder K. Angewandte Chemie - International Edition, 2007 , vol. 46, # 11 p. 1893 - 1896
Route2
- 88001-42-7
- ~82%
- In-stock
  
  25070-74-0
References
- BRISTOL-MYERS SQUIBB COMPANY Patent: WO2005/12249 A2, 2005 ; Location in patent: Page/Page column 40 ; WO 2005/012249 A2
Route3
- 123-75-1
- 91806-74-5
- ~85%
- In-stock
  
  25070-74-0
References
- Kashima, Choji; Tsuruoka, Shiro; Mizuhara, Saori Tetrahedron, 1998 , vol. 54, # 49 p. 14679 - 14688

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H317
Precautionary Statements : P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P501

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

TPSA 29.54
LogP 2.419
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 2

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

1-Cbz-pyrrolidine sigma1-Cbz-pyrrolidine manufacturer1-Cbz-pyrrolidine price1-Cbz-pyrrolidine structure1-Cbz-pyrrolidine SDSbuy 1-Cbz-pyrrolidine1-Cbz-pyrrolidine supplier1-Cbz-pyrrolidine uses1-Cbz-pyrrolidine molecular weightprice of 1-Cbz-pyrrolidine1-Cbz-pyrrolidine chemical name formula of 1-Cbz-pyrrolidine

Salutation:	*Country or Region:
*Applicant Name:	*Organization Name:
*Email Address:	Quantity:
CAS NO. :	Product Name:
Remarks:
Upload Pictures

CAS.No.		Product Name
Applicant Name *		Email Address *
Phone Number *		Organization Name*
Country or Region*		Quantity*
Remarks:

Product Name:
Cat. No.: .		CAS NO. :
Quantity:

1-Cbz-pyrrolidine

CAS No. 25070-74-0

Recommended Products

General Information

Description

Application

Synthesis

References

References

References

Safety Information

Quality Control

Computational Chemistry Data

Similar Products

Other Classifications

Recently Viewed Products

Key Words