Thalidomide-iodo

Name: Thalidomide-iodo
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 2509137-01-1
Cat. No. CS-0641697
Purity≥98%
MDL No.MFCD31735039

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Structure of 2509137-01-1

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Description

Thalidomide-iodo integrates a reactive iododirecting group into the thalidomide scaffold, enabling site-specific bioconjugation. This derivative facilitates targeted protein labeling and probe development through halogen-based coupling strategies. The iodo functionality enhances reactivity in palladium-catalyzed cross-coupling processes while maintaining the parent molecule’s biological profile.

Application

Thalidomide-iodo serves as a versatile iodinated derivative for late-stage functionalization in medicinal chemistry, enabling site-selective cross-coupling reactions via its reactive C–I bond. The molecule retains the core phthalimide-glutamic acid scaffold of thalidomide, offering a platform for targeted modifications while maintaining structural integrity under standard coupling conditions. Its bench-stable nature and compatibility with palladium-catalyzed transformations facilitate efficient diversification of immunomodulatory scaffolds.

General Information

CAS No. 2509137-01-1
Cat. No. CS-0641697
Purity ≥98%
MDL No. MFCD31735039
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₃H₉IN₂O₄
Molecular Weight 384.13
Synonym(s) None
SMILES O=C1C2=CC=C(C=C2C(N1C3C(NC(CC3)=O)=O)=O)I

Computational Chemistry Data

TPSA 83.55
LogP 0.5465
H_Acceptors 6
H_Donors 1
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Functional Group Iodide

Building Blocks Skeleton Aromatic heterocycle compounds Indolin compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Life Science PROTAC Ligands for E3 Ligase

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

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Thalidomide-iodo

CAS No. 2509137-01-1

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