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CS-W001157 4
Total: USD 88.00

Thalidomide-iodo

  • CAS No. 2509137-01-1

  • Cat. No. CS-0641697
  • Purity≥98%
  • MDL No.MFCD31735039

*For research and further manufacturing use only, not for direct human use.

Thalidomide-iodo|CS-0641697

Structure of 2509137-01-1

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General Information

  • CAS No. 2509137-01-1
  • Cat. No. CS-0641697
  • Purity ≥98%
  • MDL No. MFCD31735039
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₉IN₂O₄
  • Molecular Weight 384.13
  • Synonym(s) None
  • SMILES O=C1C2=CC=C(C=C2C(N1C3C(NC(CC3)=O)=O)=O)I

Description

Thalidomide-iodo integrates a reactive iododirecting group into the thalidomide scaffold, enabling site-specific bioconjugation. This derivative facilitates targeted protein labeling and probe development through halogen-based coupling strategies. The iodo functionality enhances reactivity in palladium-catalyzed cross-coupling processes while maintaining the parent molecule’s biological profile.

Application

Thalidomide-iodo serves as a versatile iodinated derivative for late-stage functionalization in medicinal chemistry, enabling site-selective cross-coupling reactions via its reactive C–I bond. The molecule retains the core phthalimide-glutamic acid scaffold of thalidomide, offering a platform for targeted modifications while maintaining structural integrity under standard coupling conditions. Its bench-stable nature and compatibility with palladium-catalyzed transformations facilitate efficient diversification of immunomodulatory scaffolds.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   83.55
  • LogP   0.5465
  • H_Acceptors   6
  • H_Donors   1
  • Rotatable_Bonds   1

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