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CS-W001157 4
Total: USD 88.00

Propargyl-PEG2-NHS ester

  • CAS No. 2512228-06-5

  • Cat. No. CS-0167730
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Propargyl-PEG2-NHS ester|CS-0167730

Structure of 2512228-06-5

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Description

Propargyl-PEG2-NHS ester enables site-specific conjugation in aqueous media, combining a reactive NHS group with a terminal alkyne for bioorthogonal labeling. This bifunctional linker features a short PEG spacer that enhances solubility and reduces steric hindrance, facilitating efficient coupling to primary amines on proteins, antibodies, or peptides while preserving functional integrity.

Application

Propargyl-PEG2-NHS ester serves as a versatile bifunctional linker for conjugation chemistry, enabling efficient coupling of biomolecules to surfaces or solid supports via its reactive NHS ester group. The propargyl moiety provides a bioorthogonal handle for copper-catalyzed azide-alkyne cycloaddition (CuAAC), facilitating site-specific labeling and assembly of functionalized constructs. Its PEG2 spacer enhances solubility and reduces non-specific binding, while the reagent exhibits excellent bench stability and ease of purification—ideal for applications in probe synthesis, protein modification, and materials science.

General Information

  • CAS No. 2512228-06-5
  • Cat. No. CS-0167730
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₁₅NO₆
  • Molecular Weight 269.25
  • Synonym(s) None
  • SMILES O=C(CCOCCOCC#C)ON1C(CCC1=O)=O

Computational Chemistry Data

  • TPSA   82.14
  • LogP   -0.3499
  • H_Acceptors   6
  • H_Donors   0
  • Rotatable_Bonds   8

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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