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CS-W001157 4
Total: USD 88.00

DMT-2'-O-MOE-rA(Bz) phosphoramidite

  • CAS No. 251647-53-7

  • Cat. No. CS-0023727
  • Molecule weight932.01
  • Purity≥97%
  • MDL No.MFCD29472587

*For research and further manufacturing use only, not for direct human use.

DMT-2'-O-MOE-rA(Bz) phosphoramidite|CS-0023727

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General Information

  • CAS No. 251647-53-7
  • Cat. No. CS-0023727
  • Purity ≥97%
  • MDL No. MFCD29472587
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅₀H₅₈N₇O₉P
  • Molecular Weight 932.01
  • Synonym(s) 2'-O-Moe-A(Bz)-3'-Phosphoramidite
  • SMILES O=C(C1=CC=CC=C1)NC2=NC=NC3=C2N=CN3[C@H]4[C@H](OCCOC)[C@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](COC(C5=CC=C(OC)C=C5)(C6=CC=CC=C6)C7=CC=C(OC)C=C7)O4

Description

Molybdenum(IV) selenide is used in transistors and photodetectors. It is also used as a solid lubricant. Further, it is used in piezoelectric and solar cells.

Application

DMT-2'-O-MOE-rA(Bz) phosphoramidite serves as a key building block for the synthesis of modified oligonucleotides, enabling site-specific incorporation of 2'-O-methoxyethyl (MOE) ribose modifications. The protected adenine base (Bz) ensures orthogonal compatibility during solid-phase synthesis, while the dimethoxytrityl (DMT) group provides efficient monitoring and purification via chromatographic separation. This reagent exhibits excellent stability, high coupling efficiency, and compatibility with standard desalting and HPLC purification protocols, making it ideal for applications requiring enhanced nuclease resistance and binding affinity in antisense and RNA therapeutics.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

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Computational Chemistry Data

  • TPSA   173.57
  • LogP   8.65218
  • H_Acceptors   15
  • H_Donors   1
  • Rotatable_Bonds   22

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