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CS-W001157 4
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(R)-tert-Butyl (2-oxopyrrolidin-3-yl)carbamate

  • CAS No. 251938-49-5

  • Cat. No. CS-0054207
  • Purity≥97%
  • MDL No.MFCD11616145

*For research and further manufacturing use only, not for direct human use.

(R)-tert-Butyl (2-oxopyrrolidin-3-yl)carbamate|CS-0054207

Structure of 251938-49-5

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General Information

  • CAS No. 251938-49-5
  • Cat. No. CS-0054207
  • Purity ≥97%
  • MDL No. MFCD11616145
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₆N₂O₃
  • Molecular Weight 200.23
  • Synonym(s) tert-butyl N-[(3R)-2-oxopyrrolidin-3-yl]carbamate
  • SMILES O=C(OC(C)(C)C)N[C@H]1C(NCC1)=O

Description

(R)-tert-Butyl (2-oxopyrrolidin-3-yl)carbamate serves as a chiral building block for pyrrolidine-based scaffolds in medicinal chemistry. This bench-stable, moisture-tolerant reagent features a protected (R)-configured pyrrolidin-3-yl moiety, enabling direct incorporation into peptide sequences and heterocyclic systems under standard conditions.

Application

(R)-tert-Butyl (2-oxopyrrolidin-3-yl)carbamate serves as a versatile chiral building block in medicinal chemistry, enabling efficient access to pyrrolidine-containing scaffolds. Its robust tert-butyl carbamate protection offers excellent bench stability and facilitates straightforward deprotection under mild acidic conditions. The molecule functions effectively in peptide coupling and asymmetric synthesis, with high functional group tolerance and compatibility in standard reaction workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   67.43
  • LogP   0.3996
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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