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Structure of 25199-84-2
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2-Hydroxy-4-(trifluoromethyl)quinoline features a strategically positioned trifluoromethyl group that enhances electron-withdrawing character and metabolic stability. The phenolic hydroxyl enables hydrogen bonding and facilitates conjugation in synthetic scaffolds. This compound serves as a key building block in medicinal chemistry, particularly for developing kinase inhibitors and fluorescent probes.
2-Hydroxy-4-(trifluoromethyl)quinoline serves as a versatile scaffold in medicinal chemistry, enabling efficient access to bioactive heterocycles. Its trifluoromethyl group enhances metabolic stability and membrane permeability, while the phenolic hydroxyl facilitates downstream functionalization via etherification or metal-catalyzed coupling. The compound exhibits bench stability and compatibility with standard purification methods, making it a practical building block for lead optimization campaigns targeting kinase inhibitors and other pharmaceutical candidates.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: