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Structure of 25263-44-9
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(3-Hydroxyphenyl)acetonitrile features a phenolic hydroxyl group ortho to a nitrile-bearing side chain, enabling direct incorporation into bioactive scaffolds. This combination imparts enhanced solubility and reactivity in synthetic transformations, particularly in coupling reactions requiring polar functional handles. The molecule exhibits bench-stable behavior under standard conditions and serves as a key intermediate in the development of pharmaceutical analogs and fluorescent probes.
(3-Hydroxyphenyl)acetonitrile serves as a versatile building block in medicinal chemistry, enabling direct access to substituted benzodioxole and hydroxycinnamamide scaffolds. Its nitrile group facilitates efficient transformations via hydrolysis or nucleophilic addition, while the ortho-hydroxyl moiety supports directed metalation and orthogonal protection strategies. The compound exhibits good bench stability and is compatible with standard purification methods, making it well-suited for iterative synthesis campaigns and API intermediate development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: