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CS-W001157 4
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Ethyl 5-(chloromethyl)furan-2-carboxylate

  • CAS No. 2528-00-9

  • Cat. No. CS-W005896
  • Purity≥98%
  • MDL No.MFCD00173837

*For research and further manufacturing use only, not for direct human use.

Ethyl 5-(chloromethyl)furan-2-carboxylate|CS-W005896

Structure of 2528-00-9

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General Information

  • CAS No. 2528-00-9
  • Cat. No. CS-W005896
  • Purity ≥98%
  • MDL No. MFCD00173837
  • Storage -20°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉ClO₃
  • Molecular Weight 188.61
  • Synonym(s) Ethyl 5-Chloromethyl-2-Furancarboxylate
  • SMILES CCOC(=O)C1=CC=C(CCl)O1

Description

Ethyl 5-(chloromethyl)furan-2-carboxylate features a reactive chloromethyl group at the 5-position of a furan ring, enabling direct functionalization in synthetic sequences. This bench-stable, moisture-tolerant reagent integrates readily into C–C and C–heteroatom bond-forming reactions, offering efficient access to substituted furan architectures under standard conditions.

Application

Ethyl 5-(chloromethyl)furan-2-carboxylate serves as a versatile building block for furan-based heterocycles, enabling efficient functionalization at the C5 position. The chloromethyl group facilitates nucleophilic substitution, allowing rapid access to diverse derivatives via displacement reactions. Its bench-stable nature and compatibility with standard synthetic protocols make it well-suited for medicinal chemistry campaigns and process-scale applications.

Synthesis

  • Route1
    • null|null
      50-00-0
    • In-stock
      Ethyl 2-furancarboxylate|CS-0015334
      614-99-3
    • ~98%
    • In-stock
      Ethyl 5-(chloromethyl)furan-2-carboxylate|CS-W005896
      2528-00-9

    References

    • MERCK PATENT GMBH Patent: WO2007/14619 A1, 2007 ; Location in patent: Page/Page column 26-27 ; WO 2007/014619 A1
  • Route2
    • null|null
      76448-73-2
    • ~%
    • In-stock
      Ethyl 5-(chloromethyl)furan-2-carboxylate|CS-W005896
      2528-00-9

    References

    • Journal of the Chemical Society, , p. 667,670
  • Route3

    References

    • Journal of the Chemical Society, , p. 667,670

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3265
Class : 8
Packing Group : Ⅱ
Hazard Statements : H302-H314
Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P304+P340-P330-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   39.44
  • LogP   2.1951
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   3

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