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1,1-Dimethylethyl 1,2-dihydro-2-oxospiro[3H-indole-3,4'-piperidine]-1'-carboxylate

  • CAS No. 252882-60-3

  • Cat. No. CS-W020737
  • Purity≥98%
  • MDL No.MFCD10566051

*For research and further manufacturing use only, not for direct human use.

1,1-Dimethylethyl 1,2-dihydro-2-oxospiro[3H-indole-3,4'-piperidine]-1'-carboxylate|CS-W020737

Structure of 252882-60-3

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General Information

  • CAS No. 252882-60-3
  • Cat. No. CS-W020737
  • Purity ≥98%
  • MDL No. MFCD10566051
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₇H₂₂N₂O₃
  • Molecular Weight 302.37
  • Synonym(s) tert-Butyl 2-oxospiro[indoline-3,4'-piperidine]-1'-carboxylate; 1'-Boc-1,2-dihydro-2-oxo-spiro[3H-indole-3,4'-piperidine]
  • SMILES O=C(N1CCC2(CC1)C(NC3=C2C=CC=C3)=O)OC(C)(C)C

Synthesis

  • Route1

    References

    • JANSSEN RandD IRELAND; TAHRI, Abdellah; VENDEVILLE, Sandrine Marie Helene; JONCKERS, Tim Hugo Maria; RABOISSON, Pierre Jean-Marie Bernard; HU, Lili; DEMIN, Samuël Dominique; COOYMANS, Ludwig Paul Patent: WO2014/60411 A1, 2014 ; Location in patent: Page/Page column 36; 37 ;
  • Route2
    • In-stock
      Oxindole|CS-M2997
      59-48-3
    • null|null
      118753-70-1
    • ~83%
    • In-stock
      1,1-Dimethylethyl 1,2-dihydro-2-oxospiro[3H-indole-3,4'-piperidine]-1'-carboxylate|CS-W020737
      252882-60-3

    References

    • Vachal, Petr; Miao, Shouwu; Pierce, Joan M.; Guiadeen, Deodial; Colandrea, Vincent J.; Wyvratt, Matthew J.; Salowe, Scott P.; Sonatore, Lisa M.; Milligan, James A.; Hajdu, Richard; Gollapudi, Anantha; Keohane, Carol A.; Lingham, Russell B.; Mandala, Suzanne M.; Demartino, Julie A.; Tong, Xinchun; Wolff, Michael; Steinhuebel, Dietrich; Kieczykowski, Gerard R.; Fleitz, Fred J.; Chapman, Kevin; Athanasopoulos, John; Adam, Gregory; Akyuz, Can D.; Jena, Dhirendra K.; Lusen, Jeffrey W.; Meng, Juncai; Stein, Benjamin D.; Xia, Lei; Sherer, Edward C.; Hale, Jeffrey J. Journal of Medicinal Chemistry, 2012 , vol. 55, # 7 p. 2945 - 2959
  • Route3
    • null|null
      293744-34-0
    • ~%
    • In-stock
      1,1-Dimethylethyl 1,2-dihydro-2-oxospiro[3H-indole-3,4'-piperidine]-1'-carboxylate|CS-W020737
      252882-60-3

    References

    • WO2007/28638 A1, ; Page/Page column 96 ; WO 2007/028638 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   58.64
  • LogP   2.9074
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   0

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