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CS-W001157 4
Total: USD 88.00

Cyclopropyl trifluoromethanesulfonate

  • CAS No. 25354-42-1

  • Cat. No. CS-0169340
  • Purity≥95%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Cyclopropyl trifluoromethanesulfonate|CS-0169340

Structure of 25354-42-1

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Description

Cyclopropyl trifluoromethanesulfonate serves as a highly reactive triflate ester for cyclopropyl transfer in cross-coupling and functionalization reactions. The strained cyclopropyl ring enhances electrophilicity, while the trifluoromethylsulfonyl group ensures excellent leaving group ability. This combination enables efficient C–C bond formation under mild conditions.

Application

Cyclopropyl trifluoromethanesulfonate serves as a highly reactive cyclopropyl transfer agent in transition-metal-catalyzed cross-coupling reactions. Its triflate leaving group enables efficient C–C bond formation under mild conditions, facilitating the direct introduction of cyclopropyl motifs into complex molecular architectures. The stability of the cyclopropyl ring and the robustness of the triflate functionality make this reagent particularly valuable for constructing bioactive scaffolds and natural product analogs with high functional group tolerance and predictable stereochemical outcomes.

General Information

  • CAS No. 25354-42-1
  • Cat. No. CS-0169340
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅F₃O₃S
  • Molecular Weight 190.14
  • Synonym(s) Methanesulfonic acid, trifluoro-, cyclopropyl ester
  • SMILES O=S(C(F)(F)F)(OC1CC1)=O

Computational Chemistry Data

  • TPSA   43.37
  • LogP   1.015
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   2

Safety Information

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GHS Pictogram :
GHS No : GHS02,GHS05,GHS07
Signal Word : Danger
UN#: 2924
Class : 3,8
Packing Group :
Hazard Statements : H225-H302-H314
Precautionary Statements : P210-P233-P240-P241-P242-P243-P260-P264-P270-P280-P301+P330+P331-P304+P340-P330-P363-P370+P378-P405-P501

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