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CS-W001157 4
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1-(2-Aminophenyl)ethanone hydrochloride

  • CAS No. 25384-14-9

  • Cat. No. CS-W017640
  • Purity≥95%
  • MDL No.MFCD00035477

*For research and further manufacturing use only, not for direct human use.

1-(2-Aminophenyl)ethanone hydrochloride|CS-W017640

Structure of 25384-14-9

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General Information

  • CAS No. 25384-14-9
  • Cat. No. CS-W017640
  • Purity ≥95%
  • MDL No. MFCD00035477
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₀ClNO
  • Molecular Weight 171.62
  • Synonym(s) 2'-Aminoacetophenone Hydrochloride
  • SMILES CC(C1=CC=CC=C1N)=O.[H]Cl

Description

1-(2-Aminophenyl)ethanone hydrochloride features a benzene ring bearing both an amino group and a ketone functionality, enabling direct coupling in transition metal-catalyzed reactions. The protonated amine enhances solubility in aqueous media while maintaining stability under standard bench conditions. This form facilitates efficient incorporation into pharmaceutical intermediates and functionalized aromatic scaffolds.

Application

1-(2-Aminophenyl)ethanone hydrochloride serves as a versatile building block for the synthesis of heterocyclic scaffolds and bioactive molecules. Its ortho-aminobenzoyl functionality enables direct participation in cyclization reactions, including imine formation and electrophilic substitution. The hydrochloride salt enhances solubility and stability in aqueous and polar organic media, facilitating handling and purification in standard synthetic workflows.

Synthesis

  • Route1
    • 2'-Aminoacetophenone Linagliptin Impurity|CS-0229112
      551-93-9
    • ~%
    • In-stock
      1-(2-Aminophenyl)ethanone hydrochloride|CS-W017640
      25384-14-9

    References

    • Organic Letters, , vol. 14, # 1 p. 288 - 291
  • Route2

    References

    • Journal of Organic Chemistry, , vol. 47, # 18 p. 3577 - 3581

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   43.09
  • LogP   1.8932
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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