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Structure of 25850-22-0
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This bench-stable amine features a rigid tetrahydropyran core with a sterically shielded dimethyl substitution, enhancing metabolic stability. The primary amine functionality enables straightforward conjugation and incorporation into bioactive scaffolds.
2,2-Dimethyltetrahydro-2H-pyran-4-ylamine serves as a versatile heterocyclic building block for medicinal chemistry and process development. Its tertiary amine functionality enables efficient salt formation and solubility modulation, while the rigid pyran scaffold provides conformational stability. The geminal dimethyl substitution enhances metabolic resistance and bench stability, facilitating straightforward purification. It functions effectively in amide coupling, alkylation, and transition-metal-catalyzed cross-coupling reactions, supporting rapid diversification in API lead optimization.
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GHS Pictogram :
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GHS No : GHS02,GHS05
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Signal Word : Danger
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UN#: 1993
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Class : 3
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Packing Group : Ⅱ
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Hazard Statements : H226-H302-H318
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Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501
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Lot numbers can be found on the outside label of a product: