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Structure of 258506-66-0
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2-Chloro-6-iodopyridine is a halogenated pyridine derivative featuring complementary reactive sites for cross-coupling. The chlorine and iodine substituents enable sequential functionalization, with the iodine group facilitating efficient Pd-catalyzed coupling and the chlorine offering orthogonal reactivity. This dual-halogenation pattern supports modular synthesis in medicinal chemistry and materials science.
2-Chloro-6-iodopyridine serves as a versatile bifunctional building block in cross-coupling chemistry, enabling sequential functionalization at the 2- and 6-positions of the pyridine ring. The chlorine atom facilitates palladium-catalyzed coupling reactions under mild conditions, while the iodide group offers high reactivity in Suzuki, Stille, Negishi, and Sonogashira transformations. Its bench-stable nature and orthogonal reactivity profile make it ideal for constructing complex heterocyclic scaffolds in medicinal chemistry and materials science.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: