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Structure of 259209-20-6
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5-Fluoro-2-hydroxybenzeneboronic acid features a boronic acid group ortho to a phenolic hydroxyl, enabling efficient Suzuki-Miyaura coupling. The electron-withdrawing fluorine substituent enhances reactivity and stabilizes the boronate intermediate under physiological conditions. This bench-stable derivative integrates readily into complex molecular architectures with high functional group tolerance.
5-Fluoro-2-hydroxybenzeneboronic acid serves as a versatile building block in Suzuki-Miyaura coupling reactions, enabling efficient C–C bond formation under mild conditions. Its ortho-hydroxyl group enhances boronate stability and facilitates chelation-assisted coupling, while the fluorine substituent provides orthogonal reactivity and metabolic stability in bioactive molecule synthesis. The compound exhibits excellent bench stability, simplifies purification, and functions reliably in complex molecular architectures.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: